Nonspecific ulcerative colitis is a chronic inflammation of the colon.

This disease manifests itself in the form of ulcers on the mucous membrane of the colon caused by inflammation. Typical symptoms include abdominal pain, diarrhea and intestinal bleeding.

Ulcerative colitis has similar mechanisms to another chronic inflammatory bowel disease known as Crohn’s disease. Both diseases are long-term and affect the intestines, and their duration can reach tens of years. In the United States, for example, they affect between 500 thousand and 2 million people. Ulcerative colitis is equally common among men and women and most often develops during adolescence or young adulthood, although it can also occur in childhood or old age.

Causes of ulcerative colitis

Nonspecific ulcerative colitis, like Crohn’s disease, causes inflammation and ulcers on the mucous membrane of the colon. Unlike Crohn’s disease, which can affect different areas of the colon, ulcerative colitis is often limited to one area, usually starting in the rectum.

The exact cause of ulcerative colitis has not yet been established. It is known that stress is not a direct cause of the disease, although it can aggravate its symptoms. Among the suspected causes of ulcerative colitis today are:

  1. Immune disorders. Researchers suggest that certain bacteria or viruses may cause ulcerative colitis by causing inflammation of the gastrointestinal tract and activation of the immune system. The hypothesis of autoimmune processes, in which the immune system attacks colon tissue, is also considered.
  2. Genetic factors. Because the risk of developing ulcerative colitis increases in people with a family history of the disease, scientists are studying genetic predisposition to the condition. However, most patients with ulcerative colitis do not have a family history of the disease.

Manifestations of nonspecific ulcerative colitis

The symptoms of ulcerative colitis can vary, depending on the severity of the inflammatory process and the location of its occurrence. For this reason, ulcerative colitis is often classified according to the location of the process.

  • Ulcerative proctitis. In this form of colitis, inflammation affects the rectum. In some patients, intestinal bleeding may be the only sign of the disease. Some may experience pain in the rectum and a feeling of urge.
  • Proctosigmoiditis. In this form of the disease, inflammation affects the rectum and sigmoid colon. The most common symptoms include bloody stools, diarrhea, abdominal pain, and the inability to defecate despite the urge (tenesmus).
  • Left-sided colitis. In this case, the process of inflammation affects the large intestine from the rectum to the entire descending section. Manifestations of left-sided colitis include bloody diarrhea, pain in the left side of the abdomen, and unexplained weight loss.
  • Pancolitis. With pancolitis, the inflammatory process affects almost the entire colon. Symptoms of pancolitis include bloody stools, diarrhea, abdominal pain, fatigue, and severe weight loss.
  • Fulminant colitis. This is a rare, life-threatening condition that affects the entire large intestine and occurs very quickly. It is characterized by profuse diarrhea, severe pain, and sometimes dehydration. Fulminant colitis has a high risk of complications, including intestinal rupture and toxic megacolon, a condition in which the intestine rapidly dilates.

The course of ulcerative colitis varies, with periods of exacerbation and remission. However, over time, the severity of the disease remains constant.

Treatment of ulcerative colitis with stem cells

The use of stem cells in the treatment of ulcerative colitis is based on their unique ability to replace lost or damaged intestinal cells with healthy ones.

These cells, upon reaching the affected area in the intestine, transform into normal cells of the intestinal mucosa, promoting its regeneration. It is important to emphasize that stem cells play a key role in the formation of new blood vessels, thereby ensuring blood circulation in the intestinal mucosa, bypassing damaged areas.

As a result of biotherapy, restoration of damaged areas of the colon wall, healing of ulcers and reduction of scar tissue are observed, which is confirmed by colonoscopy and fluoroscopy.

A feature of biotherapy for nonspecific ulcerative colitis is the absence of contraindications and complications typical of other drug treatments, as well as the possibility of its combination with traditional approaches to treatment.




Depending on the patient’s condition (the stage of disease, the presence of complications and concomitant diseases, etc.), the doctors of our clinics can make changes and additions to the treatment program according to the patient’s needs.

We warn that the effectiveness of Stem Cell Therapy depends on many factors (the patient’s age, concomitant diseases and complications, individual characteristics of the body, genetic predisposition, lifestyle, etc.), so the expected result of treatment may differ from the actual result. In addition, we draw attention to the fact that the recovery of patients after Stem Cell Therapy should be implemented as part of a comprehensive approach to the treatment. Stem Cell Therapy can be combined with other therapeutic methods. This increases the effectiveness of the main therapy. Therefore, we recommend that you continue your rehabilitation and follow all your doctor’s advice on drug treatment of the disease in parallel with Stem Cell Therapy. This is a crucial point for achieving a sustainable result.

 We provide the most comfortable conditions of stay and excellent client service to our patients:

  • free transfer (the patients are taken to the Clinic from railway stations or airports and back);
  • selecting and booking the most transport-accessible hotel (only accommodation is paid);
  • оur clinics have facilities for the comfortable stay of people with disabilities.

 Our clinics have everything you need for treatment: our laboratory for the cultivation of Stem Cells, biobanks for storage, and the best specialists in Regenerative medicine who constantly improve their skills to help our patients with the most modern and safe methods.

We try to make our patients feel at home in the clinic and the entire treatment process goes smoothly.

You need to consult with the doctors to get complete information about the possibility of Stem Cell Therapy specifically in your case. Sign up for a free consultation with the specialists of the clinic and give yourself the opportunity to live an active and full life!


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