Study shows adipose tissue co-regulates cognitive function

In mice, cognitive decline is influenced by obesity due to the potential association of an adipose-brain axis. To examine this proposal, Núria Olivera-Canellas, and a team of researchers in the departments of medicine and diabetes at the University of Girona, Spain, identified 188 genes by using RNA sequencing of adipose tissue in three patient cohorts associated with cognitive performance. The genes had associations with synaptic function, anti-inflammatory signaling, vitamin metabolism, phosphatidylinositol metabolism and the complement cascade.